Curb Your Adrenaline, Improve Your Health – Dr. Michael Platt

Curb Your Adrenaline, Improve Your Health – Dr. Michael Platt



bulletproof radio a state of high performance you're listening to bulletproof radio with Dave Asprey today's cool fact of the day is about adrenaline it turns out it has short term superpowers adrenaline also known as epinephrine is a neurotransmitter it's made mostly by your adrenal glands and your body secretes it in a moment of crisis and it gets ready to meet an emergency oh say a tiger eating you your boss yelling at you someone cutting you off in traffic or whatever you perceive as an emergency even if it's just something that really wasn't an emergency and makes your heart beat faster and increases blood flow to your muscles and it helps to use oxygen more efficiently and it turns on your nervous system in interesting ways that causes the neurons in your brain to fire two to three times faster that could be interesting because in a study mice and rats who were exposed to a maze in a previous day could navigate the maze with more correct choices when they were injected with adrenaline does that mean adrenaline is a form of nootropic or a smart drug maybe sorta because a journal it does act like a chemical messenger in your brain to make you more alerts during those stressful times it can distract your brain from sending pain signals and redirect your attention on your immediate tasks like that running away from a tiger thing even if you stub your toe it can stop an allergic reaction by increasing blood pressure and relaxing muscles in your airway so you can actually breathe and you get something called hysterical strength from certain amounts of adrenaline that allows say mothers to lift cars off their injured children and it even gives you a better eyesight by cueing muscles of your iris to contract so that your pupils can expand and no you don't have to eat carrots to do that or even take eye armor pretty interesting that adrenaline could do this and yes you may have guessed that we are going to be talking about adrenaline today on the show now today's guest has spent a very long time looking at adrenaline and other other neurotransmitters and other parts of aging bioidentical hormones the board-certified internal medicine specialist with about four decades of experience working directly with patients everything from medical groups to elder care to health research and he runs something called the Platte Wellness Center in Rancho Mirage where he's looking at the root causes of illness and this whole show is going to be about one of his things he study in his life's work I'm talking about dr. Michael Platt by the way but in his 40 years of practice he's looked at what happens when we get excess adrenaline and what he's come up with here which is also in literature of course is that things like fibromyalgia autism ADHD bipolar disorder depression anger weight gain and addictions are a part of excess adrenaline in how another hormone that's typically used in hormone replacement therapy for women called progesterone can help to fix the problem so relation to the show going what the heck here's the deal if you're alive and you have social media you probably have excess adrenaline or maybe even not enough adrenaline because you've burned yourself out listen to the show it is going to describe you or someone that you know Michael welcome to the show thank you for having me alright did you get interested in new in a in adrenaline just because you're a native New Yorker and New Yorkers are always angry is that how it works that's a good point but I've been doing hormones for a long time and and one of the advantages that I had is that when I saw patients i sat down and talked to them for about two hours and when you sit down and talk to a patient you you learn a lot and I started seeing a certain pattern and so I started putting you know things together and it came up with excess adrenaline is the underlying cause of a lot of conditions that and some of them were felt to be incurable why why isn't everyone talking about this you know that's an excellent question I don't really have the answer for you but you know part of part of the problem you allow me to bend a little bit sure is that doctors are not trained to treat the cause of illness you know they're basically trained to give out band-aids to treat the cause of illness and and they actually get very little training in hormones and you know so part of this project related to you know our friends the drug companies who control what doctors learn in medical school they control the FDA the control the medical courts have control medicine and and we and if you don't mind my saying so and I hope they're not part of your sponsors but you you know for the most part drug companies have no interest in people being healthy now there's there's no drug companies sponsoring Bulova Freddie I don't think you have to worry about that well it's just yeah so so it's you know I've written a book as you may know called adrenaline dominance yeah and as far as you know it's the only book that's ever been written that that talks about adrenaline and the clinical consequences and the conditions related to it and why it happens and how to fix it and so doctors it's it's a whole concept that has not been taught to doctors but one of the the things that brings me great joy is just finding these things that that are massive problems that we just didn't see if for whatever reason and then shining a little bit of light on them because it changes sometimes millions of people's lives toxic mold is an example there in fact there's a tie with adrenaline there where toxic mold will cause an adrenal response and people who are sensitive to it you walk into a moldy building you get a surge of adrenaline as your body's like deal with all this but people don't know about that generally so they just wonder I don't know I have a headache and I don't feel good and all these word problems happen and I know the it I know the incidence of that but how big of a deal is adrenaline dominant time is this five percent of the population is it fifty percent of the population well you know if you look at the number of people with ADHD m'u it's kind of growing yeah and and if you and then you know you mentioned fibromyalgia there there are ten million people in this country with fibromyalgia they've all been told that there's no cure for in fact doctors don't even know what caused the pain of fibromyalgia but it's an easy condition to actually eliminate you know once you treat the cause of fibromyalgia you can actually get rid of ADHD by treating the cause of 88 and you're saying it's always too much adrenaline that's causing fibromyalgia and and these other conditions like that's I'm at the time always I like what's well well I'd say let you know I don't want to say a hundred percent but certainly well into the 90s interesting all right so given that we've got a ton of people listening with ADHD in fact the majority of entrepreneurs seem to have ADHD in fact it might make you a better entrepreneur and all of the people seeking a flow state through extreme sports generally ADHD correlates very highly with that um what what is adrenalin Dominus kind of walk me through if it say as if I was new to the idea listening to the show and saying how would I know if it's me or my spouse or my kids or whatever else all your listeners have heard of adrenaline yeah and basically they know it is what they call the fight or flight hormone but and and it's released in times of danger or whatever but the fact is is that danger rarely occurs and if it does occur it's short-lived what people don't understand is that the primary reason why the body releases adrenaline is to provide fuel to the brain you know the brain per weight uses more sugar than any other part of the body and you know when you take sugar away from the brain you they call that hypoglycemia low blood sugar and and people get sleepy and especially between 3 & 4 when insulin Peaks and a lot of people get sleepy when they're driving in fact some people fall asleep when they're driving go off the road hit a tree and kill themself so you can see from a survival standpoint the body always wants to make sure the brain has enough fuel so the thing about adrenaline so it's so it's normal you know for people to release adrenaline at certain times but the but I used the term adrenaline dominance to indicate where those people have excess amounts of adrenaline to the point that it actually has clinical consequences one of the things that I wrote about in my blog post on sleep hacking people tend to wake up or people who tend to wake up at 4:00 or 5:00 in the morning and can't go back to sleep they oftentimes have had a blood sugar crash and then the way the body responds to a crash and blood sugar is adrenaline and cortisol because those are the fastest ways to raise blood sugar back up and then you go back to sleep after an adrenaline surge is that the source of this excess adrenaline or is it that these are traumatized fearful people or is it some environmental thing or like why why this change in our population or has this always been there throughout history well first of all the primary source of adrenaline is to be relationship to low sugars in the brain adrenaline actually peaks at 2:30 in the morning that's the the classic time that it's released and and because that's the time that the brain basically runs out of fuel the you know all this advice about not eating anything before going to sleep because you know is actually incorrect you know you know part of the treatment and we're going to be getting into treatment is to eat something before going to sleep so the brain has fuels so the body doesn't have to put out adrenaline to provide it you know people that have insomnia you know people that have you know the brains race or people at trouble falling asleep staying asleep people that grind their teeth at night people that keep the jaw clenched restless leg syndrome people they get up at night to urinate all related to excess adrenaline and and you mentioned you know adrenaline does create stress you know you know almost all stress is related to increased adrenaline and the body does respond to stress by putting out cortisol and you're right these two hormones come out at night and they're both raising sugar levels you know to you know be adrenalin raise your sugar levels for the brain and cortisol raise your sugar levels to deal with the stress and it's probably the number one cause of weight gain and nobody ever talks about this you know people died in exercise during the day but they put on faster in the way because any excess sugar that the body is not burn up it's stored as fat in the fat cell so if we have low sugar at night we're gonna have adrenaline if you have high sugar tonight we're gonna get fat right that sounds like blood sugar regulation might be the key here well it's the key to it you're absolutely right it's it's life you know that's that's adrenaline that's its main function what I found worked and so for ten years I've slept with sleep monitors on my head and various other parts of my body and really dug in on the physiology of this there's a group of people who if they have a tablespoon or maybe a teaspoon or two of raw honey which tends to raise liver glycogen if they do that before bed they don't wake up in the middle of night they sleep better then there's another group of people who will have a brain octane or even just a little bit of coconut oil which isn't quite as effective but it raises ketones and having slightly higher ketones which is an alternate source of energy more for the neurons versus the glial cells then they sleep better and there's a different group of people that may overlap those two who have a small amount of protein that doesn't raise insulin too much like a collagen protein and between experimenting with those three buckets people who have a hard time going to sleep or staying asleep often times just by changing a small snack we're talking you know less than a hundred calories totally changes things but the circadian researchers like dr. Sachin panda say don't eat anything after dark and that seems to work best for people who are metabolically healthy how the heck do you unravel this after 40 years of clinical practice what do you see because I'm confused I know it works for me and I know it works for different buckets but I don't know how to put someone in a bucket I take a very logical approach to to getting people better and and and if and and I know that the brain actually can use a fuel within three hours so that's why people that have problems with adrenaline they have to eat throughout the day the problem is you know adrenaline actually takes away the appetite in fact you can cause nausea and vomiting and so a lot of people with access to adrenaline don't eat breakfast because they don't have a nap so that would be almost all intermittent fasters now right because I mean this is something I do I skip breakfast well yeah I don't recommend that because you have to remember breakfast is the first meal that somebody has had since the day before and and if they skip breakfast they're gonna be living on adrenaline yeah so I I don't recommend the intermittent fasting even though for some people they can get away with it you know what it comes down says whatever works but people with access to journaling should not be doing intermittent fasting I actually when I was much younger was diagnosed with fibromyalgia and chronic fatigue and you know all these other things and I discovered through just the process of elimination and talked to a lot of people there were things in my environment that were affecting my metabolism I fixed my metabolism I don't have those problems anymore and I intermittent fast most mornings does that mean I a high adrenaline problem or what does that mean it means something else and I'm just putting myself in the mindset of similar since going but I have an intermittent fasting all this time should I stop but I feel better like what what's going on well I I hear that but you know maybe you've had access to some MCT oil somewhere along the line sure I made it popular you know empty Tyrael is part of getting people better because as you know it converts into ketones and ketones or one of the two fuels that the brain uses oh I love this all right how long have you known this for quite a while anyway okay thank you for saying that EMC Till's were like a 1980s bodybuilding thing and they were sort of largely forgotten and now they're popular and bulletproof coffee I think I think did that what I I guess this goes back to my original question Michael the knowledge about excess adrenaline the knowledge that you had about MCT oils going back a long time it just you didn't hear about it at the American Academy of anti-aging medicine you didn't hear about it in medical school you didn't hear about it in dietitian school how did you hear about it like like for people listening who want to hear about things ahead of time the way you did how did you do that you know I do I do a lot of reading and whatever and and so somewhere down the line and I don't remember where I I read that the two fuels the brain uses are glucose and ketones and and and and I understood that the reason why the body puts out all this adrenaline is just to raise sugar levels or fuel for the brain so so because of my interest in in ketones you know basically you know MCT oil and and and coconut oil which is which can convert into MCT oil there's not a whole lot of other choices you know people can go on a ketogenic diet but you know again that's a tough diet for a lot of people you know – and it cuts no slack well and also one thing that happens on unending long term keto is you're gonna get low insulin levels over time and low insulin levels are correlated with higher all cause mortality than high insulin levels so it it seems like an unending keto diet is not a good way to keep your adrenal glands healthy you even get insulin resistance from it well wellies but remember reported that fuel that the brain uses is glucose yeah and so that's carbohydrates and and actually the best source of glucose comes from comes from vegetables and which are not a big part of a ketogenic diet but but there are a good thing to add for people that have trouble with adrenaline yeah the whole the whole coconut oil MCT thing it is is a little bit of a controversy to the anti-aging group that I've that I ran for a long time in Silicon Valley first started talking about this in the late 90s and started doing a lot of work with coconut oil and all but it wasn't until about three years ago that dr. Cunnane at UC San Diego came out with really the definitive research that said hey coconut oil raises ketones as much as not eating for eight hours MCT oils the broad category of all four kinds of MCT oil essentially doubles that and then the one MCT oil caprylic acid or c8 the one that's in brain octane oil that one raises ketones four times more then then coconut oil or then just sleeping for eight hours and I certainly feel different when I can raise my ketones up like that but I'm not on a zero carb diet I'm on a very high vegetable diet something that wouldn't be possible it wouldn't be a ketogenic diet if it wasn't for the addition of brain octane do you have a number for how many ketones someone needs to deal with the adrenaline problem if you were to do a ketone measurement is it Oh point three point five one two three because the numbers are all over the place I know I think it's a good question I don't have a clue would I go by tablespoons so usually I recommend at least in the beginning that people have at least three tablespoons of MCT oil not all at once I would hope nono throughout the day know that the brain uses a fuel very quickly so that's why throughout the day you have to continue to provide fuel but you know what's interesting if I could digress just a little bit is that people really are not aware of the of how adrenaline affects lives you know it starts it starts right after childbirth you know babies that have colic that's adrenaline and and what's interesting you know there's a hormone called progesterone that actually blocks adrenaline and rubbing progestin cream on the abdomen of a baby with colic be it goes away in about three minutes and then later on in life to the terrible twos which is also related to excess adrenaline and and bedwetting and children is only related to excess adrenaline and you only see that in creative type children because creative people had the most adrenaline we'll talk about that but buddy aren't you messing with the kids hormones we give them progesterone cream I mean aren't we're talking about formation of sexual characteristics is done by agent and testosterone and progesterone can get in the way of that well progesterone that is sex hormone that interacts pretty closely with estrogen well it well actually a blocks estrogen it's an anti in hormone right but but but keeping keep in mind that the fetus when when the fetus is in the womb gets exposed to incredibly high levels of progesterone yes and and the so and the fetus is all the receptor sites for progesterone but when so does it deliver it you know all of a sudden is that sudden drop in progesterone and so if the baby we inherited a tendency toward excess adrenaline from the mother then that's where the colic comes from it's the same thing that happens with postpartum depression this always relates to excess adrenaline and and that drop in progesterone and so what's interesting is that post point depression can be eliminated with progestin just like colic can be really you know eliminated the thing about adrenaline and depression is that you know there are two types of depression you know there's this what's called a reactive depression where somebody dies or loses a job and you know and so they react to that but probably the most common type of depression is endogenous where it comes from within people are depressed they don't know why they're depressed and the most common cause of this is a current internalization of anger and adrenaline is an anger hormone you know that's what road rage comes from and so you know other other things you know that that people should be aware of is you know first of all how easy it is you know to fix excess adrenaline but there are so many other conditions you know irritable bowel syndrome you know adrenaline is a survival hormone and it cuts off blood supply to areas of the body that are needed for survival and that includes the intestines and that's why people get cold hands and cold feet it's not a low thyroid it's adrenaline and you know people that with excess adrenaline they always carry tension in the back of their neck and this can cut off blood supply to the ears and that's where tinnitus comes from and sin and tinnitus can be eliminated just by putting progestin cream on the back of the neck and and also you know eating correctly which includes the MCT oil and vegetable you know I'm trying to make people aware that all these little problems in life are fixable all right so we've got ADHD addiction fibromyalgia interstitial cystitis teeth grinding neck tension anxiety cold hands and feet insomnia even tinnitus and like each of these I know other causes and other things that will get rid of them almost all of them well I'm not none none none will eliminate tinnitus as quickly as putting progesterone in the back of the neck and with that we're here we're talking about five six minutes and this works for almost everyone and half of people with tinnitus I would say more than half I'd say probably 95% very interesting how do we know that adrenaline is not a symptom that it's a cause no I hear what you're saying but no I think it's a cause I don't see it as being a symptom here's why I'm asking a fascinating interview in the first hundred interviews on bulletproof radio with dr. Dwight Jennings and he's found through 25 years of neurological dentistry that if he adjusts the height of someone's rear molars he can get rid of tinnitus and sleep apnea and a bunch of other conditions ADHD a list that's probably a 50% overlap with the list we just talked about and the mechanism of action he describes is that it reduces substance P like the the pain signaling molecule in the body which allows the body to relax people who have a jaw misalignment will routinely have sympathetic nervous system over activation and thus excess adrenaline so he corrects the jaw adrenaline drops symptoms go away well I hear that but but I think the proximal cause um people that he's dealing with have excess adrenaline to begin with and caused a misalignment because it caused TMJ is one of the problems progresses adrenaline and and he wined it so if you fix adrenaline people's TMJ just goes away that that yes oh that's cool okay that would that would point towards a journal and being a core cause alright now we're now we're getting somewhere this is fascinating okay there's a drug called a beta blocker and I've recommended that to a few friends who you know are unable to speak in public with any other thing that does freak out so I'm like hey you should go talk to your doctor and see if you get a prescription for this stuff and see if it's medically safe and all that and then they do it and then it suppresses their excess adrenaline they're fine should everyone with this list of symptoms just take a little bit of adrenal blunting medication and be done with it well again you know here we're dealing with band-aids again well it's you know if beta-blockers Blanc adrenalin there's no question but they also have their their own little list of side effects and you know including impotence is one of the side effects and they're anti-thyroid drugs so but wouldn't it be better just to lower adrenaline to begin with of course but I'm just saying it may be wrong but I know you have 40 years of experience experimenting with this and seeing what happens clinically that's why you're on the show so I have listening to you the the wisdom of my elders is something I'm a huge fan of so our so beta blockers aren't the answer what about say taking adrenal extract so you can get glandular extracts I've used those quite quite extensively where you have the raw ingredients to at least make adrenaline are those a good idea or those not a good idea I wouldn't recommend them okay well it's just that you know you generally the term adrenal fatigue mm-hmm and it's a condition that actually doesn't exist it's a naturopath diagnosis and and the thing about naturopaths primarily they do what are called saliva tests yeah and the problem with saliva test is that when people have access to journal anit remember adrenaline is a survival hormone and it's cutting off blood supply to certain areas of the body not needed for survival which includes the salivary gland and because it cuts off blood supply to the salivary glands hormones don't get into the saliva so when they do a saliva test and get a low cortisol they diagnose adrenal fatigue if they did a blood test they would actually find that the cortisol levels are high and and and part of the problem is is that they approach adrenal fatigue they what they try to do is actually raise cortisol levels and even give Quartet which is cortisone as part of the treatment when they already have high cortisol levels so so everybody knows about adrenal fatigue nobody knows about adrenaline dominance you know you mentioned that you had chronic fatigue and and if we can go back to fibromyalgia for a little bit you know the the thing about adrenaline it remember it's the fight or flight hormone so people have a tendency to keep their muscle tense and when if people keep muscle tense they built up what's called lactic acid in the muscles and that's what causes they actually the pain of fibromyalgia it gets into the into the muscles and the tendons and and at the same time because people keep the muscle tense all the time they use up a tremendous amount of energy and that's why they have fatigue which is the other classic symptom of fibromyalgia but just by lowering adrenaline levels that you know the muscles relax now circulation can go through the muscles and clear out the acid so it takes somewhere between three days and three weeks to actually eliminate fibromyalgia even though it's people are told that that there's no cure for it so in in the three days the three weeks which is a very fast amount of time to eliminate some like fibromyalgia what are you doing to lower the excess adrenaline how do you do well well remember okay they they're two two things that need to be done number one you have to provide fuel to the brain so that adrenaline doesn't have to be released to provide fuel okay so it's a stabilized blood sugar or fuel because you know because there's there's a reason that I put brain octane in every meal I carry a little package of if I travel and I feel awesome all the time when I do that and if I skip more than a day of it my brain isn't as sharp and you're saying that's because it's providing an alternate fuel to glucose it's probably more important than glucose for the brain I would agree with you for the brain at least for short-term neuron focus right but if the the other side of fiber imagine chronic fatigue is there's autoimmunity and the glial cells the immune parts of the brain that do clean up they want glucose and they don't burn ketones well so if you're only eating ketones all the time are you going to eventually sort of not take care of the immune system of the brain well I gotta recommend just ketones they recommend glucose also okay guys so you you have some carbs and you have some ketones and you do that with mc2 oh yeah hey that's that's what I do it seems to work again let's go back to ADHD yeah yeah you know in my book I I talked about the good the bad and the ugly in terms of conditions related to excess adrenaline the only condition that have put in the good category is ADHD the most intelligent successful creative people in the world have ADHD and what were you saying oh all right what are you saying sorry I got distracted I'm kidding oh okay doesn't read each a joke exactly keep going the most intelligent successful great creative people in the world have ADHD so it's so it's not a bad thing and and it's not a learning disorder even though that's it's branded as a learning disorder it's an interest disorder people people with ADHD will focus if they're interested if they're not interesting will not focus because their mind goes so quickly so if then that interest they get distracted very easily that is true now and keep in mind that creative people had the most adrenaline and and the most six the most successful people in the world have due to different types of ADHD you know the typical type where you'd hear about like kids that are hyperactive and then the creative type which they call abd you know these are the kids that are trouble focusing but they're not hyperactive that was better than me yeah well well and and pray the heads of all just almost every corporation in the world have two different types what I call the mixed type ADHD and probably not one of them or very few of them ever finish college these are extremely intelligent people that want to do things they don't have time for college you know Bill Gates classic Steve Jobs never finished college and yet they did pretty well yep so you're saying they had a mix of creative type and typical type so they had the extra energy that comes from being hyperactive and they had the creative type so they were hyperactive only towards what they were interested in exactly well that sounds like a recipe for success to me at least that's so what I do I I don't I don't follow sports because I just don't have time and because it doesn't being that interest but you give me a study on PubMed and I just can't put it down but maybe sometimes to my detriment and so alright you follow that recipe what percentage of the population has these different kinds of ADHD now like would you guess I know you may not build a site studies I would say almost the majority of people Wow so more than half of people have at least some of this ADHD going on I would think so I you know it just says it has a bad rap you know it because they really don't understand what it is the you know for example you know they they teach children algebra and and people with ADHD have a real hard time with algebra because they're not interested in it does three Miller's and the problem is is that when they leave high school there's no need for a super anymore so what they really should do is make it an elective rather than you know a mandatory requirement i I'm just saying but they don't understand what ADHD is that is not a learning disorder interest disorder I very much love that perspective on ADHD it's it's a beautiful thing and that brings the thought that if you were to say alright it is a gift or at least it has its upside what about those will call them 49 percent of people who don't have excess adrenaline should they be you know maybe getting a little bit of an EpiPen so they can have more adrenaline so they could have a brain that's more interested in stuff that matters interesting point I yeah you know it's funny the majority in fact just about every patient I've ever seen has had excess adrenaline so it so people it so it could be that there are people out there that don't have a lot of adrenaline I don't see them it's cuz they're all sleep well they're quite very well adjusted and you know bipolar disorders are all about adrenaline what isn't you know children with autism have incredibly high levels of adrenaline and and they respond wonderfully to lowering adrenaline levels now I I was my one side of my family is mostly on the spectrum of either ADHD or Asperger's and things like that and I probably would have met the clinical diagnosis of Asperger's as a kid you know OCD Oh DD a DD all that kind of stuff oh well adrenaline all adrenaline but here's here's the question what was causing my body to make all that excess adrenaline I mean I can say it that I can tell you tell me yeah Brunson families you know okay it is absolutely genetic if you have excess adrenaline you inherited that from either one or both the appearance it just handed down always so so these are the people who were meant to go out and fight wars and be warriors and protect the village well well the people without access to adrenaline where the farmers and root gatherers I mean I'm generalizing here but is that why we evolutionarily came out this way or am I being perjorative towards people who aren't wired the way I am well you know people that do sign up to go into the military they have a lot of adrenaline to begin with you know the fight-or-flight moment and and remember that PTSD which is one of the problems to people get from the military is all about adrenaline and again responds wonderfully just to lowering adrenaline level so your your fix for this is basically MCT oil and progesterone cream and vegetables okay so okay how much progesterone cream because you can go to any any pharmacy or natural product store and they make progesterone cream that's over-the-counter you don't need a prescription for it I mean should I be like slathering this is how do I know if I'm getting too much well yeah you know one of the nice things about progesterone you can't overdose on it but in order for it to be effective five percent which means fifty milligrams per pump is the exact strength you need to block adrenaline most most of the over-the-counter progesterone czar one point six or 2% I I happen to actually have a five percent progestin cream and the website is also on Amazon which what's your website Platt wellness PL ATT Platt wellness.com okay and so it's so it's a therapeutic strength of progesterone that's available without a prescription any people use one pump of that and then blocks well this one well and before every meal now the rate there well the reason for that is that as soon as people put food in their mouth the body's putting out insulin yeah and and when inste goes up blood sugar drops and remember when blood sugar drops the body puts out more adrenaline so one of the ways of controlling adrenaline is to control insulin and that's what's nice about progesterone is that it you know it controlled both insulin and adrenaline it's really a miracle type hormone that is not really well understood by the medical community so progesterone will keep your insulin down and one of the biggest things so I know that you're also interested in anti-aging my new book on anti-aging it just hit pre-order on Amazon it's called superhuman but one of the big things that helps you prevent aging is sobbing post prandial high blood sugar and in other words after you have a meal your blood sugar spikes and that causes some of the problems in aging are you proposing that putting progesterone cream on before a meal could help with that spike in blood sugar that happens after meal well I don't I don't necessarily think it's that excess sugar that speeds up the aging I think it's the production of insulin so yes your insulin is there but but low insulin is actually more dangerous than high insulin isn't it well I'm not talking about low insulin I'm talking about yeah you know insulin is a hormone that speeds up the aging process yeah so I think it's the what you're talking about from an anti-aging standpoint well you know here you go into the field of what the called telomeres yep yeah we've definitely had several episodes on tequila murders I think a lot of the audience knows but define them for the people who maybe are new to the show well it's it's just a segment of on the end of certain chromosomes probably all chromosomes that quote telomeres and and the shorter they are the short of your lifespan but I just want to say that stress is one of the major factors that actually shortened telomeres and again you know blocking adrenalin prevent stress or eliminate stress so so from an anti-aging standpoint I would say that progesterone is way up there in terms of anti-aging if there's definitely a big role for that and I actually did a bunch of research on the postprandial problem but also talking about the role of progesterone during hormone replacement therapy and all apart from its effects on adrenaline so I mean do people you said a very big thing and I'm not sure that I fully understand it to the extent you do but I feel like some of the anti-aging experts I've interviewed if they heard you say there's no such thing as too much for just roan that they might do a backflip thing about well you you know remember I didn't doing hormones for a long time and and what I found is basically there's only one problem when in using possession is when people have have what's called type 3 diabetes which is insulin resistance in the brain yeah and and one of the characteristics of progesterone is that it increased it actually causes some degree of insulin resistance which is a good thing because it prevents people from getting sleepy and people don't get sleepy when they're driving or as a passenger when they start using progesterone I you know myself I used to slap my face when I was driving trying to keep my eyes open but it was just a low sugar from too much insulin anyway so the point is is that when people have what's called the insulin resistance in the brain and then they use progesterone right away they get even more insulin resistance and the body has even a harder time getting sugar into the brain cells and there's an immediate release of excess adrenaline so in that situation you know people that's the only downside to using progesterone but it's also a good thing because there is no test for insulin resistance in the brain you you only find out about once you develop Alzheimer's right and dil Dil Bredesen would agree wrote the end of Alzheimer's has been on the show so what you're saying is is now entering the mainstream which is awesome so so basically the only test there is to determine if somebody has type 3 diabetes or insulin resistance of the brain is using progesterone so somebody uses progesterone they get and they get you know palpitations and increasing anxiety or whatever then then the likelihood is that they either have type 3 diabetes to begin with or they just have no fuel in the brain and and the progestin is actually hindering getting Trigorin to the brain so you know but that other than that there is no i have not run into any downsides using progesterone so it's a relatively you know have relatively safe hormone when you compare it to other hormone you mentioned using it with kids I mean it's a children a DHD you'd say a pump on the back of the neck before bed or before meals or well kit kit you know kit kids with ADHD you know they can actually tolerate progesterone four times a day to begin with but people should talk to their doctor first even though stuff's available over-the-counter or you think it's so safe and and well on point you know let my people doctors don't get Iranian hormones a fair point and and and right away as soon as you mention hormones in children they'll say no but the question is you know what a big what are they what are they doing to help you know that you know I don't know it's a fair point well it's just like there's nothing nothing for children with better bed wetters nothing they used to give vasopressin an antidiuretic hormone until the fda made the stop but right now they have nothing to treat children with bedwetting but you could like i say you can get rid of bedwetting in 24 hours just by lowering adrenalin and you you have to use progesterone to do that you know you weigh the downsides and weigh the upsides and and my my feeling is that if the fetus can tolerate such incredibly I mean incredibly high levels of progesterone why can't children tolerate it you only have 40 years of treating patients I'm presuming including children with this so this clinical experience of safety is something that your you're comfortable with well when you compare it to other drugs on the market and turns safety there's no question that progesterone is a lot safer than most drugs on the market and progesterone is also you mentioned PTSD and it's really interesting when JJ virgin was on the show she talked about using progesterone after she saved her son Grant's life he was given some like a point one percent chance of living and I also I had a pretty substantial TBI a few years ago and one of the things that we did right afterwards was high-dose progesterone for a week after a hit to the head which seems to be an emerging thing to do for traumatic brain injuries but it's interesting that there's a high correlation of TBI and PTSD to the extent that Mark Gordon who's been on the show would tell you that there is no such thing as post-traumatic stress disorder unless there was a brain injury even an old one and progesterone maybe at that missing link there says if you hit yourself in the head progesterone maybe through its effects on adrenaline or is doing good things for the brain are there other reasons people might want to look at progesterone yes you're still with a little step further progression is actually the drug of choice for traumatic brain injuries and and the reason for that it immediately reduces swelling in the brain just about 90% of progesterone actually winds up in the brain so so you're absolutely correct it it is wonderful for post-traumatic you know for traumatic brain injuries but you know women that have been raped you know can sometimes point out with PTSD and with without having a head injury so I don't I don't know I you know I don't know if there has to be a head injury to correlate with PTSD I don't know logically I don't think so yeah yeah I I found that to be hard too hard to believe as well he had some pretty interesting and convincing data about that so I'm not saying that's the case or not but just that there's a definite high correlation of brain injuries so I need you felt your head as a kid something isn't quite working the way it ought to be and then if you have a metabolic disorder to your point where you don't use a glucose or you don't have enough ketones in your brain and then something bad happens and your pattern matching system gets screwed up who knows but progesterone it's interesting that it comes up throughout all of that thread and you know you're the the guy who's looking at adrenalin and progesterone what happens though I I've experimented many years ago with beta blockers because you know there some people put them in the category of nootropics in that your brain can work better if you're not dealing with too much adrenaline especially in those public speaking things unfortunately I don't have that problem but I wanted to experience them I felt like crap on even just a low dose for one day of beta blockers it was like walking through mud all the time and when I when I talked with doctors who prescribed these they said the same thing if you give these to someone's doing public speaking they might calm down enough to speak but if they get a hard question from the audience they'll be flat-footed and unable to like to bring that energy that a good speaker has onstage so if we take progesterone to blunt our adrenaline are we going to lose our adrenaline superpowers no absolutely not it'll actually enhance focusing and whatever they can actually more you know concentrate more on what they're they're dealing with you know children with autism you know they're extremely intelligent you know and that you know because of all the adrenaline and you know they can memorize a phone book these kids but they have so much adrenaline that you know any kind of stimuli is too much for them that's why they sort of avoid a lot of things but once you once you give them MCT oil and vegetables and and use progestin cream all of a sudden you know those kids that don't talk will start talking I want to address three creative type people you know because remember creative people had the most adrenaline and you know creative people are very intuitive about other people and and they have premonitions and deja vu type feelings and they when the phone rings they leave to know who it is before they answer although say I just thinking about you and people that are creative animals and small children are very attracted to creative type and and this is all because you know adrenaline as a neurotransmitter not only creates creativity in the brain but allows people to tap into the energy it goes through the air and they have the same ability as psychics clairvoyance dog whisperers horse whisperers they have the same ability great excite people but going one step further if you look at the music industry mmm the amount of drugs and alcohol in the music industry even in all in Hollywood and again we talk about creative people having the most adrenaline and nobody ever talks about this the you know Michael Jackson you know it was on you know propofol to sleep and benzodiazepines and you know Elvis Presley I mean all these music people that that have died of overdoses so when people with addictions go into rehab with detox whatever you know they get them off the drugs but as soon as they're released they go right back on the drugs or alcohol and because they're not dealing with the reason why they get addicted in the first place and so you know my feeling is that creative type people definitely should be aware of adrenaline I recently interviewed a Rick Rubin a very famous music producer and to my knowledge the drug and alcohol it is addiction is not something that that has been a part of Rick's life and I know I'm reasonably well and like he's never mentioned anything like that but as we all know they're common in the field then Rick talked about being something called a highly sensitive person what I was asking about how we identified music that had the the thing in it and then he looked at me said Dave you're a highly sensitive person you know on a different domain that than me but like I I know other people like me is being high adrenaline the same as being a highly perceptive highly sensitive person or is it a different thing there are some people with excess adrenaline that are super sensitive to everything you know they get EMF things or you know some you know they they can't use cellphones and all this you have sensitivity right yeah and you know and people have chemical sensitivities I'm pretty sure it's all related to excess adrenaline because these are usually very creative people that have all the kind of problem it definitely seems to coincide with creativity I mean my my experience of chemical sensitivity in particular is that there's almost always an environmental toxic mold approach which causes excess adrenaline hormonal dysfunction which then has all these other downstream effects including large increases in inflammatory cytokines does excess adrenaline increase inflammatory compounds in the body does it decrease them like what does it do well you know I'm gonna have to pass on that I'm not sure but but but it could be that when people have access to journaling to begin with they're just more super sensitive to all the toxic molds and and things in the environment interesting it okay and the incidence of that is about one third of the population and they have a variance in their HLA dr subtype have you found any genetic markers that say hey these are the genes that get passed down from family to family that make for these creative family is full of maybe autoimmunity and high amounts of creativity and ADHD well if somebody is creative then wonderful to their parents had to have been creative so there's a creative gene there has to be but do you don't know which one it is do you I'm not allowed to tell I I would like to know it'd be interesting so you could test someone for creativity and used CRISPR to insert or subtract the gene if they wanted it you know I'm not I'm not a scientist I am more of an observer mission yeah so I mean you've you've got this in your book you have just this an amazing list of these things that affect more than half the population at least you've one or two of these things yeah things like road rage I had a major issue that's in my 20s like I was I was a total jerk when I was young and certainly we talk about excess adrenaline I could see that being a part of this but there's a flipside when Nick Foles was on the show this is Super Bowl MVP we talked about his wife Tori's condition called pots which is essentially a low blood pressure disorder where you stand up you get low blood pressure there's not enough blood flow in your brain you feel like crap you you can't pay attention the body will compensate for pots by increasing adrenaline in order to write your blood sugar up so you don't pass out what's the role of progesterone and adrenaline in this surprisingly common condition well again because adrenaline is involved I I think the actually that the cause of pots is actually due to increased adrenaline to begin with oh he's just eating too much adrenaline causes pots but lowering adrenaline makes the symptoms worse well they have a you know what we call the positional hypotension yeah but but all the symptoms of pots of related to excess adrenaline so my feeling is that to treat the symptoms I I you know I've never had a patient with pot so it's hard for me to the but you know when it comes to road rage you know you you know sometimes people wind up going to anger management class which does absolutely nothing I think that's actually kind of funny understanding that emotions happen before thoughts I always find it kind of funny like oh I'm gonna think my way out of an emotion that was how I tried to live my life for a long time and I have a different mindset on that now but yeah reducing the source of the rage is probably gonna be more effective than learning how to think harder about the rage that's remember it only takes 24 hours to get rid of road rage it's all attacked and you're saying progesterone will solve that problem and and eating correct okay you know granted all right and maybe that that's a core part of this it's a real important part it's a huge thing in the the template and I want you to correct me if I'm wrong here but this is where I ended up after many years this is the the the genesis of the bulletproof diet book but it's a plate covered in vegetables that don't have a lot of toxins in them covered in the right kinds of fats that that are not damaged fats and seed oils and stuff like that and a moderate amount of high quality protein and that if you do that on a regular basis you'll probably overtime remove a lot of the things that are triggers for excess adrenaline and minis other conditions am I missing anything in that basic recipe no you're not I've got it all it's great a scrambled eggs cooked in MCT oil I put on a bed of spinach is like a perfect breakfast all right um it sounds good okay good deal we agree on that one and lots of veggies and remember so the keto diet of bacon pork rinds in diet soda does not work long-term you lose half your weight you'll keep the other half in inflammation and you'll probably need some extra during a lot along the way okay now fen phen you write about this in your book this is the suitable combination that they shut down what's your take on fen fen it's very different the you know first of all you know just to remind people a pen pen was used as a weight-loss type combination medications and it was extremely popular at one time there's almost a fen phen clinic on every corner the problem is you know is a combination of Fanta V and infant flora mean which are two blood to drugs that were actually used to suppress the appetite and the but doctors you know they only know what drug companies tell them and and and these were two generic drugs that were not promoted by any drug companies so they went to the PDR to look up the dose and so when they prescribed it they gave the dose for the individual kills rather than the combination and so people right away were overdose on fen phen and and the problem is is that you know there are two appetite suppressant drugs so people took the pills and stopped eating and they wouldn't lose weight because if you're not eating your metabolism stopped so they would go back to the doctor say I'm not losing anything so the doctor would keep on prescribing higher and higher dosages they did one study that was paid for by a drug company but who wanted Benton off the market and the and they rounded up 24 women from around the country that were on on 18 times the normal dose event then and this was this was the only study ever ever that showed heart valve damage but based on that study the FDA took it off the market because the FDA would never take a drug off the market based on its study with people on 18 times the normal dose but yeah FDA is just responsive to what drug companies want now the thing about Fantana took away cravings it took away cravings for food that that's why people would take it and they would actually be able to eat what you know any healthy removing cravings is massive but it took away cravings not only for food it took away cravings for alcohol cocaine cigarettes heroin it didn't matter what somebody had a craving for it within 24 hours it was gone in other words there is nothing nothing ever more effective for people getting off cigarettes or alcohol heroin anything so not not only that the combination of two pills were better than any blood-pressure pills on the market and it took away asthma took away migraine headaches you know this is why the drug companies wanted off the market it was good for just about every illness there was in addition to helping people lose weight but in order to lose weight they had you you know use the correct dose which is part of a study done by Wine trial who's the one that that invented bent and if you will but nope not doctors never read the study you know it so they didn't know what the dose was so but but it was the only thing ever ever that people with morbid obesity where they could actually lose weight without any problems and so my feeling is they should at least reintroduce it just for the morbidly obese because they have nothing i I just fundamentally believe that it's my right to decide what I put in my body and no regulatory agency has the moral authority to tell me I'm not allowed to use something I appreciate the warnings but to ban a substance like that because you know but some sort of a nanny that I did not appoint believes that they can tell me I don't have asked that so if I was morbidly obese I'd be like that's it I'm making Finn Finn in my bathtub if if there is such a thing and you can replicate Finn Finn I mean the pH en in the second part of this is like phenylalanine so there's amino acids they gave you some of the way there if people are deficient in aminos do you have a stack of amino acids that help with excess adrenaline no okay I don't want to thank you for asking in fact this goes back she's like at 17 or so years and memory there were definitely people someone who's listening the show right now will probably Google this and find it but there were people who are were replicating the vast majority of the effects of fen phen for weight loss using just amino acid stacks so I would suggest that that's worthy of things I'll see if I can find a reference to this but man just goes way back in my memory of biohacking we're coming up on the end of the show and and I've been sort of fishing around like what are the downsides to just you know slathering progesterone on and so far there aren't any in your clinical experience but what I haven't asked you where do I put it I know with with testosterone I'd put it you know like number one is perineum slash scrotum if you don't mind a little bit of grease enos there number two would be armpits if you have a lot of hair there that's a problem and number three would be abdomen with us for a testosterone does that same location set work well for progesterone or does it need a different type of tissue to absorb well actually with progesterone you wanted in the bloodstream okay and so you don't want to put it over fatty tissue interesting so over muscles or the back of the neck there then well the back of the neck is an excellent place for people that had a lot of tension in the back of the neck okay that's one of one of the two places to put it the primary place is on the forearm and you rub the two forums together because the skin is thin there's a great blood supply there you can actually put it on the upper chest because you know there are a lot of blood vessels that some people when they blush have a you know the upper chest the back of the neck the face but but basically the the forum and the back of the neck if there's tension to the back of the neck people that have cramps in their legs at night you know in their calves or their feet I think just massage some progestin cream and it'll go away in about 40 seconds people with restless leg syndrome you know who have a discomfort in their thighs they just have to rub some progesterone into their thighs and that'll go away in about 30 or 40 seconds so that this is powerful timing like those times it sound incredible okay the now testosterone by the way it should not be put as you know around hairy around hair follicles because there's a certain enzyme alpha reductase around the enzyme around the hair follicles so the upper upper inner arm is probably a better place than the axilla mmm-hmm because it let less hair there or as you mentioned in the perineal area because the hair there doesn't have that those enzyme by the way one thing you talk about here is something my wife dr. Lana does fertility coaching our first book was was the better baby book about you know what to do before and during pregnancy and we did talk about progesterone in there but she does do testing and you highlight in your book that progesterone can help women to conceive and/or prevent a miscarriage right does that mean that some conception problems and miscarriage problems are a result of excess adrenaline in the mother no that you know I know that that's that's completely separate okay but I was guessing but okay yeah the number one reason why women have trouble getting pregnant is low progesterone and the number one reason for miscarriage is low progesterone however their you know women very often get nauseated the first three months the morning because that morning sickness but there are some women with a morning sickness persists throughout the entire pregnancy and that's caused by adrenaline and that responds also very wonderfully just to lowering adrenaline levels and you know they call that hyperemesis gravidarum will women bomb throughout the entire pregnancy there's a thing called cyclical vomiting syndrome and children with a start vomiting they cancel I've had to be hospitalized again that's caused by adrenaline and there's another condition called PMDD premenstrual dysphoric disorder found in five to eight percent of women and bezel women that nobody could live with for ten days out of the month if severe anger issues severe mood swings also caused by excess adrenaline but there are so many articles that keep on saying there's no cure for it they put them on antidepressants which do nothing I'm just saying you know it just adrenalin it's just it's not even an afterthought it's just not thought about at all something something happens to a lot of the doctors who are the most innovative and the ones discovering new things like this they oftentimes get listed on websites of ill repute like quack watch alright that's me and well I mean one of my career goals was three listed on quack watch because I'm not a doctor oh my god I don't qualify because every doctor I respect has been like the people have changed the world they all get targeted by the guy who runs that thing and so one of my my most happy career achievements was when the USA Today wrote a piece about the bulletproof diet and they called they had the quack watch guy as though Dave doesn't nobody was talking about and I'm like yes I finally got my quack watch certification congratulate you and I literally mean this like the world changing people do that and so what you're talking about here using progesterone adrenaline dominance no fen-phen had benefits and it wasn't just a bad thing and all that it flies in the face of popular but probably wrong thoughts and you wrote about this in your book on on adrenal dominance and you actually this is very unusual but I think noteworthy you voluntarily surrendered your medical license in 2011 which allows you to just go out and say things that are true because they can't hold it as a club over your head anymore um what drove that what drove that decision for you yeah well what happened was doctors in my town put put in complaints to the Medical Board and the reason for that is that when their patient came to see me I took them off all their drugs because when you treat the underlying cause of illness you don't they don't need drugs so they put in complaints to the Medical Board but the Medical Board could not act on complaints from doctors they need to patient complaints and they didn't have any patient complaints so they sent in undercover patients to initiate complaints because they needed three complaints oh so they went after me probably more aggressively than any of the doctor ever in California even though no they never had a complaint they've never harmed a patient and so for five years they did everybody you know they arrested me twice they did everything they could to discourage me I spent half a million dollars trying to fight these people I finally gave up and what they wanted me to do was to stop taking people off drugs because medical boards out 100% funded by drug companies sharking and and Here I am taking people off drugs so what I refuse to stop taking people off drugs and anyway so the upshot I just surrendered my license just just to try to get them out of my life I you know I've never stopped my approach yeah so after about 40 years of clinical practice like I don't really need this license to help a lot of people I'm gonna just talk about what works and it's a common pattern people who come up with a new cause they usually get essentially demonized we should just burn them at the stake like a Galileo and then usually a generation later then everyone's like oh yeah it's obvious it wasn't obvious when I put that out there now was it and so what's happening now though which is all the point of this is that it doesn't take a generation anymore it takes about five years thank you social media people talking about what works so it's becoming very difficult to suppress the reality of how the body works even if it isn't good for certain business models you know sound Semmelweis and Lister you know it's got a lot of trouble in the turn of the century because they were telling doctors to wash their hands before surgery and they were destroyed by the medical system you know one of them committed suicide the doctors that in the early 80s that said that h pylori caused ulcers anyway they were you know but in but actually you know and then in the 1990s they got the Nobel Prize for medicine so it's it's one of those things I just want to say thanks for sticking to your guns and saying hey I've found something that works and I'm going to talk about it and I'm not gonna stop talking about it because I have the data and they have the clinical experience and doing what helps people same thing you know eating some saturated fat might actually work for you it's you know it's not a popular thing among certain certain populations but when you when you're willing to talk about and people try it and they see that it works and they get the data it's very hard to keep out a truthful idea down in today's environment and it was much easier 25 years ago now I have another question for the the final question on the show these days I mentioned earlier superhuman my new anti-aging book I've been very public in men's health about hey I'm gonna live to at least 180 I think we can do it with given what we know today and my question for you is I mean you're further along you've got more mileage than I do you're further along how how long do you think humans will live and how long do you think you can live with the knowledge that you've got what's achievable I'm just happy every day that I wake up and go breathing I don't know what's evil i you know i say if you stay away from doctors you'll live forever but that's probably not the that's probably not the only answer there are some really good doctors out there many of whom are friends I learned from I'm married to who will team who will form a team with you to help you get the results you want which is you want your body to behave and do what you wanted to do you don't know sent a prescription for a bunch of drugs so I I would temper that with stay away from the doctors who spend three minutes with you unless of course you have a broken arm and you just need to get that fixed the my first book was called the miracle of identical hormones and the experts for the Medical Board felt that the ideas in that book were so dangerous I shouldn't be practicing medicine and all the all the book talked about was treating the underlying causes of illness and getting people off medication I gotta tell you bioidentical hormones absolutely changed my life in my mid-20s I had lists testosterone than my mom I had almost no thyroid hormone like I was broken and getting those back in line completely gave me back enough energy to solve the rest of the things and then to go beyond just solving problems into I didn't know I could do this land which is where the biohacking movement came from so at this point to say bioidentical hormones are dangerous or whatever there's just no evidence to that and the people who say that are looking back at at horse urine which is where they were getting the first hormones that weren't bioidentical and so it's like a basic level research will inform anyone that you were right in your book a long time ago and that's a genie that won't go back in the bottle I don't think they can put that one back well dr. Platt thank you thank you for your work over the last four decades and for continuing to talk about adrenalin and progesterone and how it all works your book is fascinating and I do know people you know personally who have said you know I'm gonna try some progesterone and they felt massive improvements in their life I have I have yet to try progesterone before a meal but I will after this interview I certainly have borrowed my wife's progesterone cream on occasion for inflammation but I'll give it a shot again all right thanks very much again the name of your book is called or sorry the name of your book yeah adrenaline dominance adrenaline Tommen is a revolutionary approach to wellness and that's available on Amazon in places like that thank you so much for your work they had a pleasure thank you you're welcome if you liked today's show you know what to do I'm gonna suggest that you follow me on instagram because I put a lot of cool stuff about this up on Instagram especially in my stories and I'm doing a lot of work sharing things there and if you haven't had a chance to pick up your copy of superhuman or at least to pre-order your copy of that I go into a lot of details here on what you can do to live a lot longer and definitely pick up a copy of adrenaline dominance and as always if you read a book take the ten seconds to show the common courtesy of instead of tipping your author just leave a review so people know the book was worth their time have a beautiful day

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